BIOPHYSICS OF MOLECULES AND MOLECULAR MACHINES

PHYSICS 146A/230A

Quarter: Fall Quarter 2005


Outline


Schedule

Week 1
Additional Reading (Non-equilibrium Stat Mech): Chapter 2 Chapter 3 Chapter 4


Mon 9/26
Central dogma, amino acids, proteins

TR
Wed 9/28
Basics of  biological cells

TR
Fri 9/30
Diffusion I
Notes
TR
Week 2



Mon 10/3
Diffusion II
Notes
TR
Wed 10/5
Diffusion III
Notes
TR
Fri 10/7
Ionic Transport I

ZS
Week 3



Mon 10/10
Ionic Transport II

ZS
Wed 10/12
Molecular Dynamics I: thermodynamic considerations
Notes
TR
Fri 10/14
How to interpret biological signals: autocorrelation, power spectrum
Notes
ZS
Week 4



Mon 10/17
Biological ion channels, membrane pores

ZS
Wed 10/19
Surface charges
Notes
ZS
Fri 10/21
active transport: ion pumps
Notes
ZS
Week 5



Mon 10/24
free energy
Notes
TR
Wed 10/26
review session


Fri 10/28
Midterm


Week  6



Mon 10/31
Ratchets I


Wed 11/2
Ratchets II


Fri 11/4
Force measurement techniques: AFM, optical tweezers


Week 7



Mon 11/7
Molecular Dynamics II: force fields


Wed 11/9
Molecular Dynamics III: free energy calculations


Fri 11/11
Molecular dynamics example study


Week 8



Mon 11/14
Action potentials/Hodgkin-Huxley I


Wed 11/16
Action potentials/Hodgkin-Huxley II

Fri 11/18
Action potentials/Hodgkin-Huxley III

Week 9



Mon 11/21
Nanobiotechnology I


Wed 11/23
Nanobiotechnology II

Fri 11/25
no class - Thanksgiving Holiday


Week 10



Mon 11/28
Nanobiotechnology III

Wed 11/30
example study


Fri 12/2
review session