CURRICULUM VITAE

Zuzanna S. SIWY

 

Department of Physics and Astronomy, University of California, Irvine

2182 Frederick Reines Hall, Irvine, CA 92697

Tel. 1 949 824 8290

Fax 1 949 824 2174

E-mail: zsiwy@uci.edu

 

EDUCATION:

- Habilitation in Chemical Physics, awarded by the Polish National Committee of Science in July 2004 on the basis of research achievements and the dissertation: “Studies on preparation, structure and transport properties of nanopores in polymer membranes”.

- PhD in Chemical Sciences (summa cum laude), October 1997, Silesian University of Technology, Gliwice, Poland.

- MSc Eng. in Technology of Polymers, March 1995, Silesian University of Technology, Gliwice, Poland.

 

EMPLOYMENT HISTORY

 

Time	Position	Institution
July 2005 – present	Assistant Professor	Department of Physics and Astronomy, University of California, Irvine
July 2004 – present (on leave)	Adjunct with Habilitation degree	Silesian University of Technology, Strzody 9, 44-100 Gliwice, Poland
September 2003 – June 2005	Postdoctoral researcher	University of Florida, Department of Chemistry, Gainesville, FL 32611
October 2002 – March 2003	Consultant	Johnson & Johnson Pharmaceutical Research and Development, LLC, San Diego, USA
October 2000 – August 2003	Postdoctoral researcher; Fellow of the Foundation for Polish Science and the Alexander von Humboldt Foundation	Gesellschaft fuer Schwerionenforschung, 64291 Darmstadt, Germany
April 1998 – June 2004 (on leave from October 2000 to June 2004)	Adjunct with PhD degree	Silesian University of Technology, Strzody 9, 44-100 Gliwice, Poland
May 1995 – March 1998	Assistant researcher	Silesian University of Technology, Strzody 9, 44-100 Gliwice, Poland

 

ACADEMIC DINSTINCTIONS

 

2000 - Fellow of the Foundation for Polish Science

2001 - Fellow of the Alexander von Humboldt Foundation

2007-2008 – Alfred P. Sloan Fellow

 

 

 

AWARDS

1995 - Prize of the President of the Silesian University of Technology, “Omnium Studiosorum Optimo” for the best graduates from the Silesian University of Technology

1995 - Prize of the Foundation for the Silesian University of Technology for outstanding results in research

1997 - Prize of the Foundation for Polish Science for outstanding results in research

1998 - Prize of the Polish Minister of Education for the PhD Thesis

 

MEMBERSHIPS

-          The American Biophysical Society, The American Physical Society

 

SELECTED INVITED PRESENTATIONS AT CONFERENCES AND SEMINARS

-          Seminar, Department of Cell Physiology, Max-Planck Institute for Medical Research, Heidelberg, Germany, December 13, 1999.

-          Seminar, Institute of Physics, Warsaw University of Technology, Warsaw, Poland, March 29, 2000.

-          Seminar, Institute of Physics, University of Liege, Belgium, January 9, 2001.

-          Seminar, PRI Johnson&Johnson, San Diego, USA, February 28, 2002.

-          Seminar, Center for Nanoscience, University of Munich, Germany, May 17, 2002.

-          Seminar, Institute of Physics, Brookhaven National Laboratory, USA, August 30, 2002.

-          Plenary session, “Origins of 1/f Noise in Membrane Channels Currents”, 3^rd International Conference on Unsolved Problems of Noise in Physics, Biology and High Technology”, Washington, USA, September 2-7, 2002.

-          Seminar, Dept. of Physics, University of Augsburg, Augsburg, Germany, November 28, 2002.

-          Seminar, Dept. of Physics, University of California, Santa Barbara, USA, February 11, 2003.

-          Seminar, Hahn-Meitner Institute, Berlin, Germany, March 14, 2003.

-          Colloquium, Dept. of Physics, University at Buffalo, USA, Jan. 15, 2004.

-           Seminar, Dept. of Physics and Astronomy, University of California, Irvine, March 10, 2004.

-          Colloquium, Department of Electrical Engineering, University of Arizona, May 6, 2004.

-           Invited lecture, 17th Marian Smoluchowski Symposium on Statistical Physics, Zakopane, Poland, Sept. 4-9, 2004.

-          Invited Presentation for the session, “Biomedical Applications of Nanomaterials and Nanotechnology”, 2004 Eastern Analytical Symposium, November 15-18, 2004, Somerset, NJ.

-          Seminar, University of Southern Illinois, Carbondale, Feb. 3, 2005.

-          Invited Lecture, 2005 Nano Materials for Defense Applications, “Kona, Hawaii, USA, Feb. 18-22, 2005.

-          Invited lecture for the focus session: “On the Role of Noise and Stochastic Dynamics in Biology” at the American Physical Society Meeting, Los Angeles, March 21-25, 2005.

-          Invited lecture, The Sixth International Symposium on Swift Matter Heavy Ions in Matter, Aschaffenburg, Germany, May 28-31, 2005.

-          Invited participation, Nobel Symposium on Controlled Nanoscale Motion in Artificial and Biological Systems, Gothenburg, Sweden, June 13-17, 2005.

-          Invited lecture, Second Focused Workshop on Electronic Recognition of Bio-molecules, Beckmann Institute, Illinois USA, Sept. 7-9, 2005.

-          Seminar, Department of Physics and Astronomy, University of Missouri, Columbia, October 11, 2005.

-          Invited lecture at the APS Workshop on Opportunities in Biological Physics “How Physical Systems Can Help in Studying Function of Biological Systems”, Baltimore, March 12, 2006.

-          Invited lecture at the Annual Meeting of the Deutsche Physikalische Gesellschaft, Dresden, March 27 – 31, 2006.

-          Invited seminar at University of California, San Diego, Center for Theoretical Biological Physics, April 7, 2006.

-          Seminar at Chemical and Nuclear Engineering Department, University of New Mexico, Albuquerque, NM, April 18, 2006.

-          Seminar at Complex Systems Group, Los Alamos, NM, April 19, 2006.

-          Seminar at the Max-Planck Institute for Polymer Research, Mainz, Germany, July 28, 2006.

-          Lecturer at the Summer School on Biosensing with channels: faster, smaller, smarter, International University, Bremen, Bremen, July 29 – August 4, 2006.

-          Seminar at the Rush Medical College, Chicago, Il, September 25, 2006.

-          Invited lecture at 51^st Biophysical Society Meeting, Baltimore, March 3-6, 2007

 

LIST OF PUBLICATIONS IN PEER REVIEWED JOURNALS

1.   Grzywna Z.J., Siwy Z., Bashford C.L. (1996): Nonlinear Theory for Ionic Transport through Track - Etched Nuclear Filters, J. Membr. Sci. 121, 261-269.

2.   Grzywna Z.J., Siwy Z., Bashford C.L. (1996): On the Crowd Model for the Patch-Clamp Data, Cell. Mol. Biol. Lett. 1, 291-301.

3.   Grzywna Z.J., Siwy Z. (1997): Chaos in Ionic Transport through Membranes, Int. Journal of Bifurcation and Chaos 5, 1115-1123; Special Series in Nonlinear Dynamics, World Scientific, Series B, vol. 10, World Scientific Publishing Co. Pte Ltd, 329-337 (1997).

4.   Grzywna Z.J., Liebovitch L.S., Siwy Z. (1997): On the Self-Similarity of the Logistic Map, Cell. Mol. Biol. Lett. 2, 449-466.

5.   Grzywna Z.J., Krasowska M., Siwy Z. (1998): Chaos i Fraktale w Opisie Struktury i Morfologii Polimerów, Polimery 43, 225-231 (in Polish).

6.     Grzywna Z.J., Liebovitch L.S., Siwy Z. (1998): A Dual Mode Mechanism of Conductance through Fine Porous Membranes, J. Membr. Sci. 3811, 253-263.

7.     Fulinski A., Grzywna Z.J., Mellor I., Siwy Z., Usherwood P.N.R. (1998): On the Non-Markovian Character of Ionic Current Fluctuations in Membrane Channels, Phys. Rev. E 58, (1) 919-924.

8.     Grzywna Z.J., Liebovitch L.S., Siwy Z. (1999): Correspondence, J. Membr. Sci. 160, 277-279.

9.     Grzywna Z. J., Siwy Z., Fulinski A., Mellor I., Usherwood P.N.R. (1999): Chaos in the Potassium Current through Channels of Locust Muscle Membrane, Cell. Mol. Biol. Lett. 4, 37-54.

10. Siwy Z., Grzywna Z.J. (1999): On Ionic Transport through a High Conductance Locust K⁺ Channel in Various Voltages, Cell. Mol. Biol. Lett. 4 (4) 525-536.

11. Wolf A., Siwy Z., Korchev Y.E., Reber N., Spohr R. (1999): Ion Current Fluctuations in Artificial Ion Track Pores – Power Spectrum and Generalized Entropy, Cell. Mol. Biol. Lett. 4 (4) 553-565.

12. Mercik Sz., Weron K., Siwy Z. (1999): Statistical Analysis of Ionic Current Fluctuations in Membrane Channels, Phys. Rev. E 60, 7343-7348.

13. Mercik Sz., Siwy Z., Weron K. (2000): What Can Be Learned from the Analysis of Short Time Series of Ion Channel Recordings, Physica A 276, 376-390.

14. Siwy Z., Mercik Sz., Weron K. Spohr R., Wolf A., Grzywna Z.J. (2000): Comparison of Single Channel Potassium Current in Biological and Synthetic Systems - Dependence on Voltage, Acta Phys. Pol. B 31, 149-166.

15. Mercik Sz., Siwy Z., Spohr R., Weron K. (2001): Characterization of the Asymmetric Action of a Single, Pore in a Track-Etched Membrane, Acta Phys. Pol. B 32, 1605-1619.

16. Siwy Z., Mercik Sz., Weron K., Ausloos M. (2001): Application of Dwell-Time Series in Studies of Long-Range Correlation in Single Channel Ion Transport: Analysis of Ion Current through a Big Conductance Locust Potassium Channel, Physica A 297, 79-96.

17. Apel P., Korchev Y.E., Siwy Z., Spohr R., Yoshida M. (2001): Diode-Like Single Ion-Track Membrane Prepared by Electro-Stopping, Nucl. Instr. Meth. B 184, 337-346.

18. Siwy Z., Ausloos M., Ivanova K. (2002): Correlation Studies of Open and Closed State Fluctuations in an Ion Channel: Analysis of Ion Current through a Large-Conductance Locust Potassium Channel, Phys. Rev. E 65, 031907.

19. Siwy Z., Fulinski A. (2002): Origins of 1/f ^a Noise in Membrane Channels Currents, Phys. Rev. Lett. 89, 158101.

20. Siwy Z., Fulinski A. (2002): Fabrication of a Synthetic Nanopore Ion-Pump, Phys. Rev. Lett. 89, 198103 (featured e.g. in the Physical Review Focus, Wissenchaft on-line, Nature Materials, Research Technology News, The Industrial Physicist).

21. Siwy Z., Gu Y., Spohr H.A., Baur D., Wolf-Reber A., Spohr R., Apel P., Korchev Y.E. (2002): Rectification and Voltage Gating in Ion Currents in a Nanofabricated Pore, Europhys. Lett. 60, 349-355.

22. Siwy Z., Dobrev D., Neumann R., Trautmann, C., Voss K. (2003): Electro-Responsive Asymmetric Nanopores in Polyimide with Stable Ion Current Signal, Applied Physics A 76, 781-785.

23. Siwy Z., Mycielska M., Djamgoz M.B.A. (2003): Statistical and Fractal Analyses of Rat Prostate Cancer Cell Motility in Direct-Current Electric Field: Comparison of Strongly and Weakly Metastatic Cells, Eur. Biophys. J. 32, 12-21.

24. Siwy Z., Apel P., Baur D., Dobrev D. D., Korchev Y. E., Neumann R., Spohr R., Trautmann C., Voss K.-O. (2003): Preparation of Synthetic Nanopores with Transport Properties Analogous to Biological Channels, Surface Science 532-535, 1061-1066.

25. Siwy Z., Apel A., Dobrev, D.D., Neumann R., Spohr R., Trautmann C., Voss K. (2003): Ion Transport Through Asymmetric Nanopores Prepared by the Track-Etching Technique, Nucl. Instr. Meth. B 208, 143-148.

26. Enculescu I., Siwy Z., Dobrev D., Trautmann C., Toimil-Molares M.E., Neumann R., Hjort K., Spohr R. (2003): Copper Nanowires Electrodeposited in Etched Single-Ion Track Templates, Applied Physics A 77, 751-755.

27. Siwy Z., Fulinski A. (2003): Reply: Is Diffusional Model Good Enough for a Nanoscale Channel? Phys. Rev Lett. 91, 179802.

28. Siwy Z., Fulinski A. 1/f Noise in Ion Transport through Nanopores: Origins and Mechanism, AIP Conference Proceedings Vol 665(1) pp. 273-282. May 28, (2003).

29. Mara A., Siwy Z., Trautmann C., Wang, J., Kamme F. (2004): An Asymmetric Polymer Nanopore for Single Molecule Detection, Nano Letters 4, 497-501.

30. Siwy Z. and Fulinski A. (2004): A Nanodevice for Rectifying and Pumping ions, The American Journal of Physics 72, 567-574.

31. Ausloos M., Ivanova K., Siwy Z. (2004): Searching for Self-Similarity in Switching Time and Turbulent Cascades in Ion Transport through a Biochannel. A Time Delay Asymmetry, Physica A 336, 319-333.

32. Martin C.R., Siwy, Z. (2004): Molecular Filters, Pores Within Pores, Nature Materials News & Views 3, 284-285.

33. Fulinski A., Kosinska I., Siwy Z. (2004): On Validity of Continuous Modelling of Ion Transport Through Nanochannels, Europhysics Letters 67, 683-689.

34. Siwy Z., Heins E., Harrell C.C., Kohli P., Martin C.R., (2004): Conical-Nanotube Ion-Current Rectifiers: The Role of Surface Charge, J. Am. Chem. Soc. 126, 10850-10851.

35. Harrell, C.C., Kohli, P., Siwy Z., Martin C.R. (2004): DNA-Nanotube Artificial Voltage-Gated Ion Channels, J. Am. Chem. Soc. 126, 15646-15647.

36. Fulinski, A., Kosinska I.D., Siwy, Z. (2005): Transport Properties of Nanopores in Electrolyte Solutions: the Diffusional Model and Surface Currents, New Journal of Physics 7, 132 (1-18); part of Focus on Brownian Motion and Diffusion in the 21^st Century.

37. Siwy Z., Kosinska I.D., Fulinski A., Martin C.R. (2005): Asymmetric Diffusion through Asymmetric Nanopores, Phys. Rev. Lett. 94, 048102 (1-4).

38. Siwy Z., Trofin, L., Baker, L., Kohli P., Trautmann C., Martin C.R. (2005): Protein Biosensors Based on Biofunctionalized Conical Gold Nanotubes J. Am. Chem. Soc. 127, 5000-5001.

39. Schiedt B., Healy K., Morrison A.P., Neumann R., Siwy Z. (2005) Transport of Ions and Biomolecules through Single Asymmetric Nanopores in Polymer Films, Nucl. Instr. Meth. B 236, 109-116.

40. Fraser S.P., Diss J.K.J., Chioni A.-M., Mycielska M.E., Pan H., Yamaci,R.F., Pani F., Siwy Z. Krasowska M., Grzywna Z., Brackenbury W.J., Theodorou1 D., Koyutürk M.,  Kaya H., Battaloglu E., Tamburo De Bella M., Slade M.J., Tolhurst R., Palmieri C., Jiang J., Latchman D.S., Coombes R.C., Djamgoz, M.B.A. (2005) Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast Cancer Metastasis, Clinical Cancer Research 11, 5381-5389.

41. Heins E., Siwy Z., Baker L., Martin C.R. (2005) Stochastic Sensing of a Porphyrin Molecule in a Conically Shaped Abiotic Nanopore, Nano Letters 5, 1824-1529.

42. Heins E., Baker L., Siwy Z., Mota M., Martin C.R. (2005) The Effect of Crown Ether on Ion Currents through Synthetic Membranes Containing a Single Conically Shaped Nanopore J. Phys. Chem. 109, 18400-18407.

43. Harrell, C.C., Siwy, Z., Martin, C.R. (2006) Fabrication of Asymmetric Nanotubes within an Abiotic Platform, Small 2, 194-198.

44. Harrell, C.C., Choi, Y., Horne, L.P., Baker, L.A., Siwy, Z., Martin, C.R. (2006) Resistive-Pulse DNA Detection with a Conical Nanopore Sensor, Langmuir 22, 10837-10843.

45. Siwy, Z., Martin C.R. Tuning Ion Current Rectification in Synthetic Nanotubes, peer-reviewed book chapter in the book series Lecture Notes in Physics – in press (Feb. 2007).

46. Siwy, Z. (2006) Ion Current Rectification in Nanopores and Nanotubes with Broken Symmetry – Revisited, Advanced Functional Materials, 16, 735-746.

47. Siwy, Z, Powell, M., Kalman, E., Astumian, R.D., Eisenberg, R.S. (2006) Negative Incremental Resistance Induced by Calcium in Asymmetric Nanopores, Nano Letters 6, 473-477.

48. Siwy, Z, Powell, M.R., Petrov, A. Kalman, E., Trautmann C, Eisenberg, R.S. (2006) Calcium-Induced Voltage Gating in Single Conical Nanopores, Nano Letters 6, 1729-1734.

49. Vlassiouk, I., Siwy, Z. (2007) Nanofluidic diode, Nano Letters ASAP DOI: 10.1021/nl062924b.

50. Kalman, E., Healy, K., Siwy, Z. Tuning of Ion Current Rectification in Asymmetric Nanopores by Signal Mixing, Europhysics Letters, accepted.

51. Lee, J., Bartley, K.L., Siwy, Z., Palusinski, O.A. Fabrication of Digitated Energy Storage Devices using Nanostructure Templates – submitted to Journal of Electrochemical Society.

 

CONFERENCE PUBLICATIONS

1.       Grzywna Z.J., Siwy Z. (1997): Nonlinear Theory to Explain the Nature of a Single Channel Ionic Current, Cell. Mol. Biol. Lett. 2 (suppl. 2) 43-58.

2.       Siwy Z., Gu Y., Spohr H.A., Baur D., Wolf-Reber A., Spohr R., Apel P., Korchev Y.E. (2002): Nanofabricated Voltage-Gated Pore, Biophys. J. 82 (1), 1288.

 

PATENTS/PATENT APPLICATIONS:

1.       Spohr, Reimar; Apel, Yu Pavel; Korchev, Yuri; Siwy, Zuzanna; Yoshida, Masaru.  Method for Etching at Least One Ion Track to a Pore in a Membrane and Electrolytic Cell for Preparing Said Membrane.  Publ. date: March 14, 2002, PCT Int. Appl.  (2002), patent nr. WO0220877, Priority nr: DE20001044565 20000908.

2.       Siwy, Zuzanna; Dobrev, Dobri D.; Neumann, Reinhard; Trautmann, Christina; Voss, Kai.  Method of Producing Nanostructures in Membranes, and Asymmetrical Membrane.  Publ. date: August 27, 2003, Patent Nr: EP1338329, Priority nr DE20021008023 20020226

3.       Siwy, Zuzanna; Behrends, Jan; Fertig, Niels; Fulinski, Andrzej; Martin, Charles R.; Neumann, Reinhard; Trautmann, Christina; Molares, Eugenia T.  Nanodevice for Charged Particle Flow and Method for Producing Same, Publ. date: April 8, 2004, nr. WO2004028673, Priority numbers: DE20021044914 20020925; US20020254947 20020925

4.       Martin, Charles R.; Siwy, Zuzanna; Trofin, Lacramioara; Harrell, Christopher C.; Howorka, Stefan; Kohli, Punit, Chemical Particle and Biosensing with Nanopore and Nanotube Containing Membranes and Films, filing date Sept. 29, 2004, UF No. 11537.

5.       Palusinski, Olgierd, A; Lee, Jaeheon, Bartley, K.; Zareba Grzegorz; Siwy, Zuzanna, Technology for Building Capacitors Using Templates with Nano Scale Pores, invention disclosure UA05-068, filed March 2005.

6.       Palusinski, Olgierd, A; Lee, Jaeheon; Siwy, Zuzanna, One-Mask Process for Two-Sided Electrodeposition into Templated Nanostructures for Fabricating Interdigitated Energy Storage Devices (IESD), UA07-036, UC 2007-397-1, filed Jan. 2007.