Dail E. Chapman
Thursday, November 16, 2017
2120 Biological Sciences 3, the Fishbowl
The molecular motor dynein is responsible for most microtubule-driven cargo traveling towards the microtubule minus-ends, near the cell nucleus. Though biophysically, mechanisms of many dynein function are well characterized, its regulation in the cell is less understood. Recently, our lab reported that dynein-driven lipid droplet cargos are able to adapt their force production to improve transport when facing opposition to motion, a dynein function that was previously unknown. While we previously identified two important factors involved in this function, NudEL and Lis1, the work presented here will discuss other proteins involved in control of this adaptation pathway.
Lab Affiliation, Steve Gross, Developmental and Cell Biology